| Titre | Année | Couverture | Album | Remarques |
|---|---|---|---|---|
| Everybody | 1982 |  |  | Premier simple officiel de Madonna. Écrit par Madonna et produit par Mark Kamins. |
| Burning Up | 1983 |  | | |
| Holiday | 1983 |  | | Premier numéro 1 sur le palmarès Billboard Dance Club Chart |
| Lucky Star | 1983 |  | | |
| Borderline | 1984 |  | | |
| Like A Virgin | 1984 |  |  | Premier numéro 1 sur le Billboard (Hot-100 Singles) |
| Material Girl | 1985 |  | | |
| Crazy For You | 1985 |  |  | |
| Angel | 1985 |  | | On retrouve "Into The Groove" en face B. |
| Into The Groove | 1985 |  | | Parution à l'exception de l'Amérique du Nord. La chanson se retrouve sur l'édition Europe de l'album 'Like A Virgin" |
| Dress You Up | 1985 |  | | |
| Gambler | 1985 |  | | |
| Live To Tell | 1986 |  |  | |
| Papa Don't Preach | 1986 |  | | |
| True Blue | 1986 |  | | |
| Open Your Heart | 1986 |  | | |
| La Isla Bonita | 1987 |  | | |
| Who's That Girl | 1987 |  |  | |
| Causing A Commtion | 1987 |  | | |
| The Look Of Love | 1987 |  | | |
| Spotlight | 1988 |  |  | Publié au Japon seulement. |
| Like A Prayer | 1989 |  |  | |
| Express Yourself | 1989 |  | | |
| Cherish | 1989 |  | | |
| Oh Father | 1989 |  | | |
| Dear Jessie | 1989 |  | | |
| Keep It Together | 1990 |  | | |
| Vogue | 1990 |  |  | |
| Hanky Panky | 1990 |  | | |
| Justify My Love | 1990 |  |  | |
| Rescue Me | 1991 |  | | |
| This Used To Be My Playground | 1992 |  | ||
| Erotica | 1992 |  |  | |
| Deeper And Deeper | 1992 |  | | |
| Bad Girl | 1993 |  | | |
| Fever | 1993 |  | | |
| Rain | 1993 |  | | |
| Bye Bye Baby | 1993 |  | | |
| I'll Remember | 1994 |  |  | |
| Secret | 1994 |  |  | |
| Take A Bow | 1994 |  | | |
| Bedtime Story | 1995 |  | | |
| Human Nature | 1995 |  | | |
| You'll See | 1995 |  |  | |
| One More Chance | 1996 |  | | |
| Love Don't Live Here Anymore (Remix) | 1996 |  | | |
| You Must Love Me | 1996 |  |  | |
| Don't Cry For Me Argentina | 1997 |  | | |
| Another Suitcase In Another Hall | 1997 |  | | |
| Frozen | 1998 |  |  | |
| Ray Of Light | 1998 |  | | |
| Drowned World (Substitute For Love) | 1998 |  | | |
| The Power Of Goodbye | 1998 |  | | |
| Nothing Really Matters | 1999 |  | | |
| Beautiful Stranger | 1999 |  |  | |
| American Pie | 2000 |  |  | |
| Music | 2000 |  |  | |
| Don't Tell Me | 2000 |  | | |
| What It Feels Like For A Girl | 2001 |  | | |
| Die Another Day | 2002 |  |  | |
| American Life | 2003 |  | | |
| Hollywood | 2003 |  | | |
| Me Against The Music (Britney Spears feat.Madonna) | 2003 |  | ||
| Nothing Fails | 2003 |  | | |
| Love Profusion | 2003 |  | | |
| Hung Up | 2005 |  |  | |
| Sorry | 2006 |  | | |
| Get Together | 2006 |  | | |
| Jump | 2006 |  | | |
| Hey You | 2007 |  | ||
| 4 Minutes (feat. Justin Timberlake and Timbaland) | 2008 |  |  | |
| Give It 2 Me | 2008 |  | | |
| Miles Away | 2008 |  | | |
| Celebration | 2009 |  |  | |
| Revolver | 2009 |  | | |
| Give Me Your Luvin' (feat. Nicki Minaj and M.I.A.) | 2012 |  |  | |
| Girl Gone Wild | 2012 |  | | |
| Turn Up The Radio | 2012 |  | | |
| Masterpiece | 2012 | | Parution seulement en Angleterre pour les radios. | |
| Living For Love | 2014 |  |  | |
| Ghosttown | 2015 |  | | |
| Bitch I'm Madonna (feat. Nicki Minaj) | 2015 |  | | |
| Hold Tight | 2016 | | Parution exclusive pour les radios Italiennes. | |
| Medellín (with Maluma) | 2019 |  |  | |
| Crave | 2019 |  | | |
| I Rise | 2019 |  | | |
| I Don't Search I Find | 2019 |  | | |
Simples promos
