| Année | Titre | Couverture | Album | Remarques |
|---|---|---|---|---|
| 1982 | Everybody |  |  | Premier simple officiel de Madonna. Écrit par Madonna et produit par Mark Kamins. |
| 1983 | Burning Up |  | | |
| 1983 | Holiday |  | | Premier numéro 1 sur le palmarès Billboard Dance Club Chart |
| 1983 | Lucky Star |  | | |
| 1984 | Borderline |  | | |
| 1984 | Like A Virgin |  |  | Premier numéro 1 sur le Billboard (Hot-100 Singles) |
| 1985 | Material Girl |  | | |
| 1985 | Crazy For You |  |  | |
| 1985 | Angel |  | | On retrouve "Into The Groove" en face B. |
| 1985 | Into The Groove |  | | Parution à l'exception de l'Amérique du Nord. La chanson se retrouve sur l'édition Europe de l'album 'Like A Virgin" |
| 1985 | Dress You Up |  | | |
| 1985 | Gambler |  | | |
| 1986 | Live To Tell |  |  | |
| 1986 | Papa Don't Preach |  | | |
| 1986 | True Blue |  | | |
| 1986 | Open Your Heart |  | | |
| 1987 | La Isla Bonita |  | | |
| 1987 | Who's That Girl |  |  | |
| 1987 | Causing A Commtion |  | | |
| 1987 | The Look Of Love |  | | |
| 1988 | Spotlight |  |  | Publié au Japon seulement. |
| 1989 | Like A Prayer |  |  | |
| 1989 | Express Yourself |  | | |
| 1989 | Cherish |  | | |
| 1989 | Oh Father |  | | |
| 1989 | Dear Jessie |  | | |
| 1990 | Keep It Together |  | | |
| 1990 | Vogue |  |  | |
| 1990 | Hanky Panky |  | | |
| 1990 | Justify My Love |  |  | |
| 1991 | Rescue Me |  | | |
| 1992 | This Used To Be My Playground |  | ||
| 1992 | Erotica |  |  | |
| 1992 | Deeper And Deeper |  | | |
| 1993 | Bad Girl |  | | |
| 1993 | Fever |  | | |
| 1993 | Rain |  | | |
| 1993 | Bye Bye Baby |  | | |
| 1994 | I'll Remember |  |  | |
| 1994 | Secret |  |  | |
| 1994 | Take A Bow |  | | |
| 1995 | Bedtime Story |  | | |
| 1995 | Human Nature |  | | |
| 1995 | You'll See |  |  | |
| 1996 | One More Chance |  | | |
| 1996 | Love Don't Live Here Anymore (Remix) |  | | |
| 1996 | You Must Love Me |  |  | |
| 1997 | Don't Cry For Me Argentina |  | | |
| 1997 | Another Suitcase In Another Hall |  | | |
| 1998 | Frozen |  |  | |
| 1998 | Ray Of Light |  | | |
| 1998 | Drowned World (Substitute For Love) |  | | |
| 1998 | The Power Of Goodbye |  | | |
| 1999 | Nothing Really Matters |  | | |
| 1999 | Beautiful Stranger |  |  | |
| 2000 | American Pie |  |  | |
| 2000 | Music |  |  | |
| 2000 | Don't Tell Me |  | | |
| 2001 | What It Feels Like For A Girl |  | | |
| 2002 | Die Another Day |  |  | |
| 2003 | American Life |  | | |
| 2003 | Hollywood |  | | |
| 2003 | Me Against The Music (Britney Spears feat.Madonna) |  | ||
| 2003 | Nothing Fails |  | | |
| 2003 | Love Profusion |  | | |
| 2005 | Hung Up |  |  | |
| 2006 | Sorry |  | | |
| 2006 | Get Together |  | | |
| 2006 | Jump |  | | |
| 2007 | Hey You |  | ||
| 2008 | 4 Minutes (feat. Justin Timberlake and Timbaland) |  |  | |
| 2008 | Give It 2 Me |  | | |
| 2008 | Miles Away |  | | |
| 2009 | Celebration |  |  | |
| 2009 | Revolver |  | | |
| 2012 | Give Me Your Luvin' (feat. Nicki Minaj and M.I.A.) |  |  | |
| 2012 | Girl Gone Wild |  | | |
| 2012 | Turn Up The Radio |  | | |
| 2012 | Masterpiece |  | | Promo seulement en Angleterre pour les radios. |
| 2014 | Living For Love |  |  | |
| 2015 | Ghosttown |  | | |
| 2015 | Bitch I'm Madonna (feat. Nicki Minaj) |  | | |
| 2016 | Hold Tight |  | | Parution exclusive pour les radios Italiennes. |
| 2019 | Medellín (with Maluma) |  |  | |
| 2019 | Crave |  | | |
| 2019 | I Rise |  | | |
| 2019 | I Don't Search I Find |  | | |
| 2020 | Levitating (The Blessed Madonna Remix) par Dua Lipa (feat. Madonna & Missy Elliot) |  | Simple de Dua Lipa et the Blessed Madonna (featuring Madonna and Missy Elliott) |
|
| 2021 | Frozen (Sickick remixes) |  | Original remix par Dj Sickick -Fireboy DML remix (2022) -070 Shake remix (2022) -Frozen on Fire (2022) (Éditions numériques seulement) |
|
| 2022 | Break My Soul (The Queens Remix) Beyonce & Madonna |  | Remix original incluant des extraits de Vogue de Madonna et un rap inédit par Beyoncé | |
| 2022 | Material Gworrllllllll! |  | (Édition Numérique seulement) | |
| 2022 | Hung Up On Tokischa |  | Madonna X Tokischa (Édition numérique seulement) | |
| 2022 | Back That Up To The Beat (The Original 2015 Demo) |  | (Numérique seulement) | |
| 2023 | Sorry (Blond:ish, Eran Hersh, Darmon x Madonna ) |  | Blond:ish, Eran Hersh, Darmon x Madonna | |
| 2023 | Popular (The Weeknd, Madonna & Playboi Carti) |  |  | |
| 2023 | VULGAR (Madonna & Sam Smith) |  | ||
| 2026 | Bring Your Love |  |  | Duo avec Sabrina Carpenter |
| 2026 | Love Sensation |  | | |
| 2026 | Love Sensation (avec Kylie Minogue |  | | Nouvelle version remixée en duo avec Kylie Minogue |
Simples promos
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